Meaning: Petty; worthless. A small coin of little value, especially a 5-cent piece.
Synonyms: Meaningless, minor, diminutive, petty, slight, small, immaterial, meager, negligible, minute, irrelevant, unimportant, insignificant.
Use: While twenty dollars may seem like a picayune sum to you, it is a fortune to a starving person.
The hotel manager hates to deal with customers who complain about picayune issues like tiny wrinkles in their bed sheets.